Traumatic brain injuries are brain dysfunctions that are caused by an
outside blow to the head. Studies have shown marijuana helps limit brain
damage and improves recovery when administered shortly after the traumatic
Overview of Traumatic Brain Injuries
A traumatic brain injury (TBI) is a disruption of the normal function of the
brain caused by a bump or blow to the head. A mild brain injury, or
concussion, can cause temporary brain cell dysfunction, while a more serious
injury can cause the brain tissue to bruise, tear or bleed and result in
long-term complications or death.
In a TBI, the blow to the head causes damage to the brain cells. The damage
can be isolated to the point of impact or can be more widespread if the
impact causes the brain to moves back and forth within the skull. In
addition, bleeding in the brain, or swelling, can cause greater damage to
According to Mayo Clinic, additional complications can arise from TBIís,
including altered consciousness (coma, vegetative state, locked-in syndrome,
brain death, etcÖ), seizures, fluid buildup, blood vessel damage, nerve
damage, and intellectual, communication, sensory and behavioral problems.
The physical and psychological symptoms of a TBI can vary significantly and
can arise immediately after the traumatic blow or even weeks later. Physical
symptoms include a loss of consciousness or being dazed, headache, nausea or
vomiting, fatigue, sleeping difficulties, sleeping more than usual and
dizziness. Itís not uncommon for sensory problems, like blurred vision or
ear ringing to occur. Also, memory and concentration problems, mood changes
and a feeling of depression are cognitive symptoms of a TBI.
For mild brain injuries, rest and over-the-counter pain relievers for
headaches are often adequate for recovery. More severe brain injuries
require emergency care procedures to ensure oxygen, blood levels and blood
pressure remain at adequate levels. Medications may be used to help limit
secondary damage caused by fluid buildup. In some cases, surgery is required
to repair skull fractures or to relief pressure by draining fluid.
Findings: Effects of Cannabis on Traumatic Brain Injuries
Following the blow that leads to TBIís, the body releases harmful mediators
that lead to excitotoxicity, oxidative stress and inflammation and causes
secondary, delayed neuronal death (Biegon, 2004). Cannabis, however, has
been shown to offer protection to the neural system, thus reducing the
amount of brain damage (Mechoulam, Spatz & Shohami, 2002) (Mechoulam &
Shohami, 2007) (Mechoulam, Panikashvili & Shohami, 2002) (Biegon, 2004).
Itís cannabisí two major cannabinoids, tetrahydrocannabinol (THC) and
cannabidiol (CBD) that are responsible for these beneficial effects
following TBIís. Cannabinoids have been shown to act on the CB1 and CB2
receptors of the endocannibinoid system, which in turn prevents the release
of proinflammatory cytokines that are released after brain drama and cause
damage (Panikashvili, et al., 2006). Activating of the CB1 and CB2 receptors
also has been shown to stimulate the release of minocycline, which reduces
brain swelling and neurological impairment, and diffuses further injuries to
the brainís axons (Lopez-Rodriguez, et al., 2015) (Biegon, 2004).
In one study, cannabinoid administered to mice with brain injuries caused a
significant reduction of brain swelling, as well as better clinical
recovery, reduced infarct volume, and reduced brain cell death compared to
the control group (Panikashvili, et al., 2001). In another, CBD was found to
reduce acute and apoptic brain damage (Castillo, et al., 2010). Piglets with
brain injuries given CBD experienced less excitotoxicity, oxidative stress
and inflammation (Pazos, et al., 2013). Mice that had suffered an impact
brain injury showed marked recovery in object recognition and in performing
a specific task after CB1 receptors were activated (Arain, Khan, Craig &
Nakanishi, 2015). Cannabinoids have even shown to be effective at offering
neuroprotection in newborn babies that have experienced a brain injury
(Fernandez-Lopez, Lizasoain, Moro & Martinez-Orgado, 2013).
One study found that patients that had detectable levels of THC in their
bodies were less likely to die as a result of a traumatic brain injury than
those who didnít (Nguyen, et al., 2014).
States That Have Approved Medical Marijuana for Traumatic Brain Injuries
Currently, just Illinois, New
Hampshire, Washington have
approved medical marijuana specifically for the treatment of traumatic brain
A number of other states will consider allowing medical marijuana to be used
for the treatment of traumatic brain injuries with the recommendation from a
physician. These states include: California (any
debilitating illness where the medical use of marijuana has been recommended
by a physician), Connecticut (other
medical conditions may be approved by the Department of Consumer
Protection), Massachusetts (other
conditions as determined in writing by a qualifying patientís physician), Nevada (other
conditions subject to approval), Oregon (other
conditions subject to approval), and Rhode
conditions subject to approval).
D.C., any condition can be approved for medical marijuana as long as a
DC-licensed physician recommends the treatment.
Recent Studies on Cannabisí Effect on Traumatic Brain Injuries
Patients with detectable levels of THC in their bodies are less likely
to die as a result of a traumatic brain injury.
Effect of marijuana use on outcomes in traumatic brain injury.
Stimulating the CB1 receptor in mice that had experienced a brain caused
a marked recovery in memory and learning.
Cannabinoid agonist rescues learning and memory after a traumatic brain
Arain, M., Khan, M., Craig, L., and Nakanishi, S.T. (2015, March).
Cannabinoid agonist rescues learning and memory after a traumatic brain
of Clinical and Translational Neurology,
Biegon, A. (2004). Cannabinoids as neuroprotective agents in traumatic brain
Castillo, A., Tolon, M.R., Fernandez-Ruiz, J., Romero, J., Martinez-Orgado,
J. (2010, February). The neuroprotective effect of cannabidiol in an in
vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by
CB(2) and adenosine receptors. Neurobiology
Fernandez-Lopez, D., Lizasoain, I., Moro, M.A., and Martinez-Orgado, J.
(2013). Cannabinoids: Well-suited candidates for the treatment of perinatal
brain injury. Brain
Injury Prevention and Control: Traumatic Brain Injury. (2015, February 24). Centers
for Disease Control and Prevention.
Retrieved from http://www.cdc.gov/traumaticbraininjury/get_the_facts.html.
Lopez-Rodriguez, A.B., Siopi, E., Finn, D.P., Marchand-Leroux, C.,
Garcia-Segura, L.M., Jafarian-Tehrani, M., and Viveros, M.P. (2015,
January). CB1 and CB2 cannabinoid receptor antagonists prevent minocycline-induced
neuroprotection following traumatic brain injury in mice. Cerebral
Mechoulam, R., and Shohami, E. (2007, August). Endocannabinoids and
traumatic brain injury. Molecular
Mechoulam, R., Spatz, M., and Shohami, E. (2002, April 23). Endocannabinoids
and neuroprotection. Scienceís
Mechoulam, R., Panikashvili, D., and Shohami, E. (2002, February).
Cannabinoids and brain injury: therapeutic implications. Trends
in Molecular Medicine,
Nguyen, B.M., Kim, D., Bricker, S., Bongard, F., Neville, A., Putnam, B.,
Smith J., and Plurad, D. (2014, October). Effect of marijuana use on
outcomes in traumatic brain injury. The
Panikashvili, D., Shein, N.A., Mechoulam, R., Trembovler, V., Kohen, R.,
Alexandrovich, A., and Shohami, E. (2006, May). The endocannabinoid 2-AG
protects the blood-brain barrier after closed head injury and inhibits mRNA
expression of proinflammatory cytokines. Neurobiology
of Disease, 22(2),
Panikashvili, D., Simeonidou, C., Ben-Shabat, S., Hanus, L., Breuer, A.,
Mechoulam, R., Shohami, E. (2001, October). An endogenous cannabinoid (2-AG)
is neuroprotective after brain injury. Nature,
Pazos, M.R., Mohammed, N., Lafuente, H., Santos, M., Martinez-Pinilla, E.,
Moreno, E., Valdizan, E., Romero, J., Pazos, A., Franco, R., Hillard, C.J.,
Alvarez, F.J., Martinez-Orgado, J. (2013, August). Mechanisms of cannabidiol
neuroprotection in hyopoxic-ischemic newborn pigs: role of 5HT(1A) and CB2
Traumatic brain injury. (2014, May 15). Mayo
Retrieved from http://www.mayoclinic.org/diseases-conditions/traumatic-brain-injury/basics/definition/con-20029302.
►CBD Meds Store
Where and How to Buy CBD Cannabidiol Meds Online
or by Phone
You can order your CBD capsules or salve balm either
online by visiting the PayPal payment links at
CBD Meds Store, or by
phoning your order with credit or debit card details to sales manager
Phillip Fry toll-free 1-866-300-1616 or cell
1-480-310-7970 or emailing