A brief history
The endocannabinoid system is believed to have started evolving more than 600
million years ago. Endocannabinoids are present in fish, reptiles, earthworms,
leeches, amphibians, birds and mammals. Essentially, every animal with the
exception of insects.
Although there are
reports of potentially therapeutic effects of cannabis dating
back as early as the 1500’s,
research on the endocannabinoid system is relatively new. On July 18, 1990, Lisa
Matsuda and her colleagues at the National Institute of Mental Health reported
they found the DNA sequence possessing a receptor sensitive to certain
phytocannabinoids. Now that scientists knew where to look, research
possibilities surrounding cannabis greatly expanded.
The Endocannabinoid System
The endocannabinoid system consists of cannabinoid receptors (CB) and
endocannabinoids, which are compounds produced by our bodies that bind to these
identified two cannabinoid receptors, CB1 and CB2 (both are G-protein-coupled
receptors). According to studies, when activated, they can cause various effects
such as euphoria, anxiety, muscle relaxation, hunger, and inflammation
reduction. The specific effect seems to depend on which receptor is activated.
CB1 has been linked to the euphoric and anticonvulsive effects and is located on
nerve cells in the brain, spinal cord and peripheral nervous system. It’s also
been found in the endocrine and salivary glands, spleen, reproductive system;
and regions of the brain that control movement, memory and pain modulation.
Research performed on genetically engineered mice lacking CB1 receptors showed
that THC (the psychoactive compound in cannabis that causes a high) had
virtually no effect because it did not have this receptor to bind to.
CB2, on the other hand,
was said to be responsible for regulation of the immune system and the
anti-inflammatory effects of cannabinoids.
Our CB receptors
respond to these three types of cannabinoids:
Endocannabinoids — produced within our bodies
Phyto-cannabinoids — found in plants such as cannabis
Synthetic cannabinoids — manufactured chemically in a lab
Research on the various cannabinoids (or phytocannabinoids)
found in cannabis are currently taking place all across the world, and is still
considered to be in its infancy.
Over 80 cannabinoids have been found in cannabis. The two most abundant are
cannabidiol (CBD) and tetrahydrocannabinol (THC). While THC is the psychoactive
compound that gives cannabis it’s recreational tag for causing a “high,” CBD has
thus far been noted as safe and is non-psychoactive. No adverse side effects or
risks have been discovered, with the exception of minor discomfort in the
stomach when significant amounts were taken.
cannabinoids bind to CB1 and CB2 receptors to alter several biological
“CB1 receptors in high
density occur on presynaptic neuronal terminals in brain influencing
neurotransmission thereby number of functions–pain perception, inhibition of
stress reaction, regulation of motor functions, cognition, emotional
reactions, regulation of food intake, psychical homeostasis and motivation.”
Where and How to Buy CBD Cannabidiol Meds Online
or by Phone
You can order your CBD capsules or salve balm either
online by visiting the PayPal payment links at
CBD Meds Store, or by
phoning your order with credit or debit card details to sales manager Phillip
Fry toll-free 1-866-300-1616 or cell
1-480-310-7970 or emailing