The following information is presented for educational purposes only.
Medical Marijuana Inc. provides this information to provide an understanding
of the potential applications of cannabidiol. Links to third party websites
do not constitute an endorsement of these organizations by Medical Marijuana
Inc. and none should be inferred.
Fibrous dysplasia is a bone disorder that causes healthy bone to be replaced
with fibrous tissue. Studies have shown marijuana can help manage the pain
associated with the disorder.
Overview of Fibrous Dysplasia
Fibrous dysplasia is a chronic, uncommon bone disorder where scar-like
tissue develops in place of normal bone. As a result, the bone is weakened
and susceptible to deformation or fracture. The condition begins before
birth, according to the American Academy of Orthopaedic Surgeons, and is
caused by a gene mutation. Despite the abnormal bone forming before birth,
the condition typically isn’t known until childhood when the abnormal
fibrous tissue has grown and expanded, causing symptoms to arise.
There is no cure for fibrous dysplasia and surgical treatment is often
necessary to help curtail its progression. Medications are commonly used to
decrease the activity of the cells that are responsible for dissolving bone.
When surgery occurs, the affected bone is stabilized with metal implants to
fix breaks or deformities and to prevent further breaking, and the fibrous
tissue is scooped out and replaced with bone grafting. Over time, however,
the bone grafting is often absorbed and replaced again with the fibrous
The affected bone gradually becomes weaker as the fibrous tissue expands,
eventually causing pain. The weakened area of the bone is often painful and
so can the nearby healthy, and sometimes weight bearing leg and pelvis
bones, because they’re adjusting and carrying more of the load.
Findings: Effects of Cannabis on Fibrous Dysplasia
Cannabis can help those with fibrous dysplasia to manage the pain associated
with their condition. Two of the major cannabinoids in cannabis,
tetrahydrocannabinol (THC) and cannabidiol (CBD), are effective at lowering
acute and chronic pain (Jensen, Chen, Furnish & Wallace, 2015) (Baron,
2015). THC and CBD activate the cannabinoid receptors in the body, and these
receptors regulate the release of neurotransmitter and central nervous
system immune cells to manage pain levels (Woodhams, Sagar, Burston &
Cannabis has demonstrated the ability to significantly lower pain levels in
patients suffering from neuropathic and nociceptive pain, and has even shown
it can help manage pain that has proven resistant to other treatments (Boychuck,
Goddard, Mauro & Orellana, 2015). (Wallace, et al., 2015) (Lynch & Campbell,
2011). As a result, cannabis use has been found to be prevalent among the
chronic pain population, with improvements in pain, sleep and mood being the
most frequently reported reasons for use (Ware, et al., 2003).
States That Have Approved Medical Marijuana for Fibrous Dysplasia
Currently, Illinois is
the only state that has approved medical marijuana specifically for the
treatment of fibrous dysplasia.
However, several states have approved medical marijuana specifically to
treat “chronic pain.” These
states include: Alaska, Arizona, California, Colorado, Delaware, Hawaii, Maine, Maryland, Michigan, Montana, New
Mexico, Ohio, Oregon, Pennsylvania, Rhode
Island and Vermont.
The states of Nevada, New
Dakota, Montana, Ohio and Vermont allow
medical marijuana to treat “severe pain.” The states of Arkansas, Minnesota, Ohio, Pennsylvania and Washington have
approved cannabis for the treatment of “intractable pain.”
A number of other states will consider allowing medical marijuana to be used
for the treatment of fibrous dysplasia with recommendation by a physician.
These states include: California (any
debilitating illness where the medical use of marijuana has been recommended
by a physician), Connecticut (other
medical conditions may be approved by the Department of Consumer
Protection), Massachusetts (other
conditions as determined in writing by a qualifying patient’s physician), Nevada (other
conditions subject to approval), Oregon (other
conditions subject to approval), Rhode
conditions subject to approval), and Washington (any
“terminal or debilitating condition”).
D.C., any condition can be approved for medical marijuana as long as a
DC-licensed physician recommends the treatment.
Recent Studies on Cannabis’ Effect Fibrous Dysplasia
Cannabis significantly improves neuropathic pain that was resistant to
The effectiveness of cannabinoids in the management of chronic
nonmalignant neuropathic pain: a systematic review.
Baron, E.P. (2015, June). Comprehensive Review of Medicinal Marijuana,
Cannabinoids, and Therapeutic Implications in Medicine and Headache: What a
Long Strange Trip It’s Been… Headache,
Boychuck, D.G., Goddard, G., Mauro, G., and Orellana, M.F. (2015 Winter).
The effectiveness of cannabinoids in the management of chronic nonmalignant
neuropathic pain: a systematic review. Journal
of Oral & Facial Pain and Headache,
Fibrous dysplasia. (2014, July 8). Mayo
Retrieved from http://www.mayoclinic.org/diseases-conditions/fibrous-dysplasia/basics/definition/con-20032196.
Fibrous Dysplasia. (2010, June). American
Academy of Orthopaedic Surgeons.
Retrieved from http://orthoinfo.aaos.org/topic.cfm?topic=a00083.
Jensen, B., Chen, J., Furnish, T., and Wallace, M. (2015, October). Medical
Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence. Current
Pain and Headache Reports, 19(10),
Lynch, M.E., and Campbell, F. (2011, November). Cannabinoids for treatment
of chronic non-cancer pain; a systematic review of randomized trials. British
Journal of Clinical Pharmacology,
Wallace, M.S., Marcotte, T.D., Umlauf, A., Gouaux, B., and Atkinson, J.H.
(2015, July). Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy. Journal
Ware, M.A., Doyle, C.R., Woods, R., Lynch, M.E., and Clark, A.J. (2003,
March). Cannabis use for chronic non-cancer pain: results of a prospective
Woodhams, S.G., Sagar, D.R., Burston, J.J., and Chapman, V. (2015). The role
of the endocannabinoid system in pain. Handbook
of Experimental Pharmacology,
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